Supplements for Migraines

Written by Sandy Cho, MD and reviewed by Julie A. Cerrato, PhD

These 5 supplements have shown to benefit migraine sufferers.


Riboflavin (Vitamin B2) is a water-soluble vitamin, which means it is not stored in the body. Therefore, it needs to be replenished in the body every day. Riboflavin is important for body growth and red blood cell production. It is also required for energy metabolism, such as the metabolism of carbohydrates.

Studies show a deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. Therefore, riboflavin has been investigated as a treatment and/or prevention for migraine.

Studies have found significant reductions in headache frequency with daily pharmacologic doses (400 mg) of riboflavin.  Furthermore, riboflavin was demonstrated to be a safe and well-tolerated alternative in migraine prevention and treatment. It even reduced the number of abortive anti-migraine tablets (ie. Ergotamines, triptans) used in migraine sufferers.


Magnesium is another important mineral to add to your treatment plan. Magnesium deficiency is a major contributing factor to the development of migraine headaches and many of us are deficient in magnesium.The recommended amount of magnesium is 600-800 mg a day, in divided doses throughout the day. Taking it in this manner maximizes its absorption.While there are many different oral forms of Magnesium, one form that be extremely beneficial for migraine sufferers is Magnesium Threonate. This is because it is able to penetrate the brain unlike other forms of Magnesium.

Ginkgolide B

Ginkgolide B is an herbal extract derived from Ginkgo biloba. It is used not only for the acute attack of migraine headaches but is also extremely beneficial for the prevention of migraine headaches.In one study, patients with a history of migraine with auras when given  the combination of Gingkolide B, Coenzyme Q 10 and Vitamin B2 (riboflavin) demonstrated not only a decrease in the frequency of migraines with aura but also their duration.

Coenzyme Q10

Supplementation with Coq10(Ubiquinone) has demonstrated to decrease the frequency of migraines headaches.Because ubiquinone can have a blood pressure-lowering effect, it is recommended to begin at low doses. Begin at 50 mg twice a day and increase slowly over the next few weeks.

Omega 3 Fish Oil

Adding Omega 3 fish oil can help  in the prevention of migraines, especially in adolescents and young adults. In one study, Omega 3 supplementation decreased the recurrence of migraines in adolescents.Begin at a dose of 1000-2000 mg a day. This can  be slowly increased to 3-4 grams a day. As Omega 3 fish oil can thin the blood, talk with your healthcare practitioner if you are taking blood-thinning medications such as Coumadin.

Seek the advice of a health professional to see if these treatments are right for you.

Agosti R, Duke RK, Chrubasik JE, Chrubasik S. Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review. Phytomedicine 2006;13(9-10):743-6.
Dall’Acqua S, Viola G, Giorgetti M, Loi MC, Innocenti G. Two new sesquiterpene lactones from the leaves of Laurus nobilis. Chemical & pharmaceutical bulletin 2006;54 (8): 1187–1189.
Gilmore B, et al. Treatment of acute migraine headache. American Family Physician. 2011;83:271-280.
Hildreth C, Lynm C, Glass R. Migraine Headache. Journal of the American Medical Association. 2009;301(24):2608.
NINDS Migraine information page. National Institute of Neurological Disorders and Stroke
Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology. 1998 Feb;50(2):466-70.
Vaughan T. The role of food in the pathogenesis ofmigraine headache. Clin Rev Allergy. 1994;12:167-180.


Supplements for Fibromyalgia that Boost Energy

Written by Dr. Rich Snyder and reviewed by Julie A. Cerrato, PhD, AP, CYT, CAP

Two supplements have shown promise in increasing the energy in a person with fibromyalgia.


There are studies concerning fibromyalgia that tout the energy boost of D-ribose. D-ribose increases the energy to all of the cells of the body, especially the muscle cells. Supplementing with D-ribose can provide your heart with the energy boost that it needs.

  • D-ribose commonly comes in capsule or powdered form. The powdered form is preferred as you can add it to your morning drink.
  • Even though ribose is a “sugar” it will not raise blood glucose levels.
  • The recommended starting dose is 2500 mg. Increase by 2500 mg every few weeks to reach a maximum dose of 10,000 mg.
  • Higher doses than 10,000 mg can cause diarrheal symptoms in some people.

Coenzyme Q10 (Ubiquinone)

Replacement of this antioxidant can help improve fibromyalgia symptoms. It has been reported that those with fibromyalgia, as well as other chronic illnesses, can have lower than normal levels of ubiquinone in the body.

  • Begin with low doses at 50-100 mg daily and increase to twice a day after several weeks. Smaller doses taken during the day maximizes its absorption.
  • As ubiquinone can lower blood pressure, you need to closely monitor your blood pressure
  • If you have diabetes, monitor your blood glucose levels as ubiquinone can lower blood glucose levels as well.
  • Armstrong DJ, Meenagh GK et al. “Vitamin D deficiency is associated with anxiety and depression in fibromyalgia.” Clinical Rheumatology. 2007 Apr;26(4):551-4.
  • Bramwell B, Ferguson S et al. “The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial.” Alternative Medicine Reviews. 2000 Oct;5(5):455-62.
  • Bent S, Padula et al. “Valerian for sleep: a systematic review and meta-analysis.” American Journal of Medicine. 2006 Dec;119(12):1005-12.
  • Cordero MD, Cotain D et al. “Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient.”  Nutrition. 2012 Nov-Dec;28(11-12):1200-3.
  • Geenen R, Jacobs W et al. “Evaluation and management of endocrine dysfunction in fibromyalgia.” Rheumatic Diseases Clinics of North America. 2002 May;28(2):389-404.
  • Ki Cha B, Man Jung S et al. “The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.” Journal of Clinical Gastroenterology. 2012 Mar;46(3):220-7.
  • Lucas HJ, Brauch CM et al. “Fibromyalgia–new concepts of pathogenesis and treatment.” International Journal of Immunopathology and Pharmacology. 2006 Jan-Mar;19(1):5-10.
  • Teitelbaum J, Johnson C et al. “The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.” Journal of Alternative and Complementary Medicine. 2006 Nov;12(9):857-62.
  • Wikner J, Hirsch U et al. “Fibromyalgia–a syndrome associated with decreased nocturnal melatonin secretion.” Clinical Endocrinology. 1998 Aug;49(2):179-83.
  • Wilhelmsen M, Amirian I et al. “Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies.” Journal of pineal Research. 2011 Oct;51(3):270-7.
  • Younger J, Noor N et al. “Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels.” Arthritis and Rheumatism. 2013 Feb;65(2):529-38.


Redd Remedies


What does your company stand for?

“Balanced…therapeutic…trusted. These words drive our passion to create holistic, natural health and wellness solutions. Redd Remedies is committed to providing an effective selection of high quality, natural supplements that work quickly to deliver results and provide meaningful support for the entire body. True to our promise, Redd Remedies helps you put your health in order.”


At Ease PMWhat is your most popular product?

“At Ease PM”


Why do people love it?

“At Ease PM helps you to fall asleep and stay asleep all night long, so that you can awake refreshed. The gluten-free, vegetarian capsules contain an all-natural blend that includes b-vitamins, magnesium and lemon balm to promote healthy transmitter levels in the brain, promote muscle relaxation and calm nervous tension at bedtime.”


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MacroLife Naturals


What does your company stand for?

“The philosophy at MacroLife Naturals is simple:
Find the purest, non-allergenic ingredients in the world and blend them into synergistic formulas that promote health and wellness!

MacroLife Greens


What is your most popular product?

“The most popular product is the 10oz Macro Greens.”


Why do people love it?

“The Macro Greens formula is known to be the best tasting greens on the market. Besides that people love the fact that is a mother and son owned company. On top of that the product itself is non-GMO, vegan friendly and also gluten free.

Once people begin to take the product they feel overall better than before.”


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Amazon Origins


What does your company stand for?

“Amazon Origins core mission is to craft products emphasizing the nutritional secrets from deep in the Amazon, improving the quality of life for everyone.”


AmaçariWhat is your most popular product?

“Amaçari is our 100% whole fruit Camu Camu supplement.”


Why do people love it?

“People love Amaçari for it’s immune, cognitive, anti-aging and overall wellness attributes. The Camu berry is a unique superfruit that contains a myriad of naturally occurring nutrients that our body is fully capable of absorbing. Amaçari is a 100% functional food ingredient concentrated into a pure powder form.


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What does your company stand for?

“Barlean’s manufactures and distributes high quality organic flaxseed oils, fish oils, green superfoods and other premium supplements in both liquid and softgels. Barlean’s is family owned and operated with a fishing heritage dating back four generations. Recognized internationally as the “Omega-3 Specialists,” Barlean’s is the winner of multiple awards for the freshest and highest quality products.”



What is your most popular product?

“Omega-3 solutions (flaxseed oil, fish oil and chia seeds).”


Why do people love it?

“Family owned and operated makers of the finest and freshest organic flaxseed oil, Fresh Catch fish oil, green food supplements and other premium essential fatty acid products. Barlean’s is GMP compliant and guarantees that every pure & pristine drop is the freshest and best tasting.

All Barlean’s products are 100% satisfaction guaranteed.”


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Eli Nutrition


What does your company stand for?

“Eli Nutrition is a company focused on making cutting edge scientific research on a variety of conditions available to all Americans through products created with safe and natural ingredients.”

TummyzenWhat is your most popular product?

“Tummyzen, a natural, safe, fast-acting and long-lasting solution to heartburn.”


Why do people love it?

“Backed by research from the Yale School of Medicine, Tummyzen uses a revolutionary formula with ingredients declared safe by the FDA and proven effective through human trials, and it provides fast-acting heartburn relief that lasts six times longer than other antacids.


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Trovita Health Science


What does your company stand for?

“Trovita Health Science is an emerging specialty health and nutrition company, dedicated to developing and commercializing products that address unmet needs in medical and performance nutrition. Nutritional health is foundational for achieving your goals, whether battling an illness or striving for optimum athletic performance.

Our mission is to offer products that are designed to help people achieve their own personal goals. We never use added sugars or corn syrup, and we leave out ingredients that we know may cause digestive problems. Our products are naturally enhanced with ingredients selected by doctors and dietitians, to bring out the best in you.”


ENU1428-Bottles-2UpWhat is your most popular product?

“Our lead product is ENU, our line of complete, naturally enhanced nutritional shakes. ENU is the only ready to drink true meal replacement shake available today – offering nearly 500 calories per serving, primarily from prudent sources like quinoa, brown rice, tapioca and a blend of healthy fats.

With 25g of protein and 24 vitamins and minerals per serving, ENU delivers the proper levels of nutrition for people who need it the most. ENU is gluten and lactose free for easier digestion.

ENU is recommended by Registered Dietitians at major cancer hospitals, eating disorder clinics, and is used by elite athletes to fuel their performance.”


Why do people love it?

“First of all, ENU has an amazing taste and texture. People are surprised at by the smooth and creamy texture, without any aftertaste or grit. And ENU is also having a meaningful impact on people’s nutritional status during difficult medical treatments.

Molly D. wrote a 5-star review on recently and this is what she had to say, “This product is literally saving my life! I am a cancer survivor going through the final stages of chemotherapy, and all foods taste terrible. This protein drink is the only nourishment I can tolerate! My nutritionist recommended this product and advised two a day for me-a perfect regimen for protein and vitamin replacement!”


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Migraines – UK Statistics and Remedies

1 in 7 people in the United Kingdom suffer from migraines; that’s 610,000 people! Migraines affect twice as many women as men.

This image, from Napiers, suggests herbal and supplement remedies to relieve the affects of a migraine.


Migraine statistics


Optimizing Vitamins and Supplements Guide

Optimizing Vitamins and Supplements Guide infographic was found on and produced by  Healthspan, a UK vitamins and supplements supplier.

Optimizing Vitamins and Supplements Guide

Related Products

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Migraine Infographic

Migraine's 4 stages and natural holistic remedies

Migraine’s 4 stages and natural holistic remedies

Read about Natural Holistic Therapies for Migraines that formed the basis for the infographic above


Supplements – 5 supplements (Riboflavin, Magnesium, Ginkgolide B, Coq10, Omega 3) have shown to benefit migraine sufferers.

Herbs – Feverfew and butterbur are popular herbs that are commonly used to provide relief from migraines.

Biofeedback – This relaxation technique uses special equipment to teach you how to monitor and control certain physical responses related to stress, such as muscle tension.

CranioSacral Therapy – CranioSacral therapy is a form of treatment which has its origins in osteopathy and can be very effective in the treatment of migraine headaches.

Meditation – Meditation, an age-old technique of mentally concentrating to have resolution, can help treat migraine symptoms both physically and emotionally.

Essential Oils – Lavender oil is touted as being one of the best for migraine pain management.

Heat & Cold Therapy – Apply hot & cold compresses to the head or neck can be helpful in relieving pain & tension.

Homeopathy – Delivered at small homeopathic dosages, the SNRA molecule has shown to be fast-acting in migraine relief.



We all know how important a varied diet is to our overall health but sometimes even good eating habits can use a little boost. Fortunately that’s where supplements come in.

Supplements exist in a variety of shapes and sizes from pills and powders to beverages and bars. Contents run the gamut from vitamins and minerals to herbs and enzymes to fish oils, probiotics and more.

According to the Centers for Disease Control and Prevention, use of dietary supplements increased by over ten percent from 42 percent in the late 1980s to mid 1990s to 53 percent by 2003-2006.

How It Works

Different supplements provide different benefits. Folic acid, for example, is important for pregnant women to take as it can lessen the chance of birth defects while calcium and vitamin D can help encourage bone health. Multivitamins which contain at least three vitamins are the most commonly taken supplement though many vitamins and minerals can also be purchased individually.

Supplements are not strictly limited to vitamins and minerals, however. Echinacea is an herb many swear by to help lessen cold symptoms and duration of illness. Fish oil can usually be found in a softgel tablet and may help with heart health. Probiotics may assist in improving digestive issues.


Benefits of supplements vary depending on the type and its designated purpose. It is important to note that the best way to meet daily nutritional needs is through a healthy diet featuring a variety of foods. When eating habits fall short, however, supplements can provide a useful nutritional edge.


Just because supplements can be purchased over the counter doesn’t mean buyers shouldn’t do their homework. Some can interfere with medications or increase the chance of bleeding.

Many are water soluble with extra amounts simply being excreted but a few exist that are not and can build up in the body to dangerously high levels. In addition, some foods like cereals and breads are fortified with extra vitamins and minerals so beware how much is being ingested through the daily diet before beginning supplementation.

Also, it’s important to keep in mind supplements are not regulated by the Food and Drug Administration in the same way over-the-counter medications are and are not intended to actually prevent or treat diseases. To ensure the supplement contains what it says it contains (and not harmful contaminants), look for the seals of approval from U.S. Pharmacopeia, NSF International or

If in doubt be sure to discuss use of supplements with a medical professional.


While there is no substitute for a healthy diet, supplements can be useful for a variety of purposes including providing a nutritional benefit and addressing a specific issue like building stronger bones or fighting a cold.


  • Dietary Supplements: What you Need to Know from the National Institutes of Health Office of Dietary Supplements
  • Dietary Supplements: What You Need to Know from the FDA